CXCL8 and fibrosis: Liver damage indicators (e.g., such as ballooning, bridging, infiltrating Kupffer cells, polymorphonuclear neutrophils, pericellular fibrosis, portal fibrosis, and portal inflammation) showed positive correlations with IL-8, suggesting that IL-8 plays a crucial role in systemic inflammation progression and, more importantly, contributes significantly to the escalating severity of liver disease in NAFLD [57].