Novais et al. showed that treatment with a quercetin and dasatinib combination prevented age-dependent IDD progression in mice, based on the significant decrease in the senescence markers p16INK4a, p19ARF and the SASP molecules IL-6 and MMP-13 and the amelioration of cell viability, phenotype and ECM content [65]. This evidence concerns the gene CDKN2A and intervertebral disk degenerative disorder.