Indeed, curcumin/SLNs inhibited the expression of the inflammatory factors TNF-α and IL-6 in IL-1β-treated rat NP IVD cells in vitro, while the GelMA scaffold successfully promoted the restoration of collagen type II and aggrecan expression levels in a rat IDD model in vivo [120]. The gene discussed is ACAN; the disease is intervertebral disk degenerative disorder.