CDKN2A and intervertebral disk degenerative disorder: Most importantly, polydatin’s senotherapeutic activity was confirmed in vivo because its oral administration suppressed senescence and ameliorated IDD development in a rat tail IVD-punctured model (as shown by the decrease of p53 and p16INK4a expression and the positive alcian blue staining in the IVD tissues, the recovery of the MRI signal intensity and the lower Pfirmann grades) [63].