IGF1 and cancer: Among its multiple biological activities lie anti-inflammatory, anti-cancer, anti-diabetic, anti-microbial, context-dependent pro- or anti-oxidant, cell cycle-regulating, estrogenic-regulating and neuroprotective activities, exerted through the modulation of numerous signaling molecules and pathways, including epidermal growth factor (EGF), VEGF, insulin-like growth factor-I (IGF-I), TLRs, NF-κB, MAPKs, PI3K/Akt, STAT3 and SIRT6 [59,178,179,180].