VEGFA and cancer: These activities are mediated by signaling molecules and pathways such as NF-ĸB, MAPK, PI3K/Akt, SIRT1, NLRP3 inflammasome, VEGF, MMPs, cell cycle regulators, etc., and have found application in the prevention or treatment of numerous (mainly age-associated) diseases and pathological conditions (i.e., cardiovascular diseases, neuropathy, retinopathy, nephropathy, cancer, urinary and dental infections, photodamage, blood circulation problems, ocular disorders, musculoskeletal disorders) [213,214].