CDKN2A and intervertebral disk degenerative disorder: More specifically, regarding its anti-senescence effect, quercetin decreased p16INK4a, p21WAF1 and SASP molecules (MMP-3, MMP-13, IL-6 and IL-8) expression, as well as SA-β-Gal activity in IL-1β-treated human NP IVD cells via NF-kB signaling through Nrf2 in vitro and ameliorated the IDD process in a puncture-induced rat IDD model [66].