In vivo, morroniside has been shown to decrease to a great extent the elevated expression of p53 and p21WAF1 and positive SA-β-Gal staining, while it significantly alleviated the decrease in aggrecan and increase in ADAMTS-5 in the NP tissues of a lumbar spine instability surgery-induced mouse IDD model. Here, ADAMTS5 is linked to intervertebral disk degenerative disorder.