Next, we examined the susceptibility of Polε-defective strains to non-azole drugs like amphotericin B (Amp B), 5FC, 5FU, caspofungin, berberine, and cyclosporine A. Amp B is commonly used to treat aspergillosis, candidiasis, and cryptococcosis, and resistance to Amp B by Candida species is rarely found in clinical settings. This evidence concerns the gene POLE and cryptococcosis.