In a randomized, placebo-controlled trial, a 4-week daily supplementation of Wellmune WGP® at a dose of 250 mg/day during the allergy season to individuals suffering from ragweed allergy significantly reduced total allergy symptoms and symptom severity by 28% and 52%, respectively, and improved quality of life by 56%, but did not affect serum IgE levels [75]. This evidence concerns the gene IGHE and allergic disease.