Dectin-1 plays a major role in innate resistance to murine Coccidioides infection and one difference between the C57BL/6 mice and the DBA/2 is a base-pair change in intron 3 of the Clec7a gene in C57/BL6 mice that leads to splicing out of the exon that encodes most of the stalk of Dectin-1, resulting in a truncated version of Dectin-1 (see Section 2.4.1). This evidence concerns the gene CLEC7A and coccidioidomycosis.