CHEK2 and breast cancer: Different risks factors have been associated to developing breast cancer in men including obesity, family history of breast cancer, black race, and exposure of the breast to ionizing radiation, among others [4]; however, the two most significant factors that have been described are carrying a diagnosis of Klinefelter’s syndrome and having a predisposition germline genetic mutation (BRCA2, BRCA1, CHEK2, PALB2) [5,6,7].