The following sections will discuss the recent understanding of well-characterized RBPs, including RBM20, RBM24, RBPMS, RBPMS2, RBFOX1, RBFOX2, and several readers of mRNA methylation, such as IGF2BP2 and YTHDC1, associated with cardiomyopathy in humans and/or animal models. Here, RBM20 is linked to cardiomyopathy.