Furthermore, CD8+ TEX (CD8TEX) is driven by massive immunosuppressive signals including nutrient deficiency, hypoxia, proinflammatory cytokines, and chronic T-cell receptor signaling in the tumor microenvironment (TME), which is regarded as the main responder to ICB, and is correlated with poor prognosis in numerous cancers [11]. This evidence concerns the gene CD8A and cancer.