The Kaplan–Meier curve of the high- and low-risk patients based on the expression of risk genes in the TCGA cohort demonstrated that SPOCK2 and MEG3 were positively correlated with the OS of patients with PACA, while MT1X, LIPH, RARRES3, and EMP1 were negatively correlated with the OS of patients with PACA (Figure 7B). The gene discussed is MEG3; the disease is permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome.