However, Raghuwansh et al. reported a decrease in serum lipids, body weight, abdominal subcutaneous fat (SAT) with preserved visceral adipose tissue, and muscle 18 months before PC diagnosis and found that the overexpression of uncoupling protein1 (UCP1) in SAT exposed the patients to PC exosomes [25]. The gene discussed is UCP1; the disease is pachyonychia congenita.