IL-6 is a proinflammatory cytokine related to disease severity and unfavorable outcomes such as ICU stay, ARDS, and severe disease; as a matter of fact, monoclonal antibody Tocilizumab is commonly prescribed to patients affected with the most severe forms of COVID-19 (Table 4) [33,34,35,36]. This evidence concerns the gene IL6 and acute respiratory distress syndrome.