In the multivariate analysis performed with PIV, NLR, PLR, and cut-off values determined for clinical characteristics and amyloidosis, PIV (odds ratio [OR], 3.133; 95% confidence interval [CI], 1.406–6.978; p = 0.005), CRP (OR, 1.139; 95% CI, 1.059–1.225; p < 0.001), presence of the M694V homozygous mutation (OR, 3.714; 95% CI, 1.869–7.379; p < 0.001), and RDW (OR, 1.131; 95% CI, 1.007–1.270; p = 0.038) were identified as independent risk factors for moderate-to-severe disease (Table 6). Here, CRP is linked to amyloidosis.