Indeed, some papers reported as a macrocategory the umbrella term of “tumefactive inflammation” [8], grouping together different neurological diseases on the basis of an etiopathogenetic mechanism of immune-mediated damage, such as multiple sclerosis (MS), neuromyelitis optica (NMO), myelin oligodendrocyte glycoprotein antibody disease (MOGAD) [9], neurosarcoidosis, and PACNS [10]. This evidence concerns the gene MOG and neuromyelitis optica.