While there is currently no evidence of molecular mimicry related to COVID-19 vaccines, the detection of anti-MOG antibodies and anti-AQP4 antibodies after receiving COVID-19 vaccines suggests potential similarities in the amino acid sequences of MOG, AQP4, and the spike (S) protein of SARS-CoV-2 virus or other unidentified immunological and inflammatory mechanisms. Here, MOG is linked to COVID-19.