Other elements that have been tested as immunoregulators in proinflammatory conditions are small peptides such as SLPI and Trappin-2/Elafin with WAP domains, which have been proven in vitro and in vivo to inhibit and revert tissue damage caused by immune cell infiltration and the presence of cytokines and chemokines in the myocardium or intestinal epithelium affected by chronic diseases [183] or from viral infections such as the encephalomyocarditis virus or Herpes virus [184,185]. The gene discussed is PI3; the disease is viral infectious disease.