As far as T-cell malignancies are concerned, molecular alteration of GATA3 has been associated with early T-cell precursor acute lymphoblastic leukemia, and immunostochemical expression of GATA3 protein in peripheral T-cell lymphoma (ranging from 20 to 40%) has been linked to reduced overall survival [9]. The gene discussed is GATA3; the disease is acute lymphoblastic leukemia.