It would be of interest, in future studies, to analyze the immunohistochemical expression patterns of NF-kB and Notch proteins in HRS cells in relation to the GATA3 expression patterns (positive vs negative cases) to gain further insight into the potential biological and clinical significance of the heterogenous expression patterns of GATA3 in HRS cells in cHL. Here, NFKB1 is linked to classic Hodgkin lymphoma.