Since constitutive activity of NF-kB and Notch pathways is a hallmark of HRS cells [20,21,22,23] and, as mentioned above, Stanelle et al. have linked GATA3 expression in HRS cells to the constitutive activity of NF-kB and Notch pathways, the GATA3 negativity in a sizeable portion of cHL cases requires further studies to be explained [12,13,14,15]. Here, NFKB1 is linked to classic Hodgkin lymphoma.