In recent years, it has become clear that many signaling pathways originating from the B-cell receptor (BCR) are involved in the development, survival, and proliferation of normal B lymphocytes: such signals are implicated, both in a tonic manner and through constitutive activation following punctual mutations, in the pathogenesis of indolent and aggressive B-cell lymphomas. Here, BCR is linked to B-cell non-Hodgkin lymphoma.