Lymphoplasmacytic lymphoma/Waldestrom’s macroglobulinemia is associated in approximately 90% of cases with a point mutation (L265P) of the MYD88 gene, a protein of the Toll-like receptor-dependent signaling pathway, whose constitutive activation determines increased cell proliferation by activation direct and indirect (through Bruton’s Tyrosin Kinase) of NF-κB [12]. Here, MYD88 is linked to lymphoplasmacytic lymphoma.