A reasonable approach to identify most DH/TH lymphomas is to analyze with FISH only the lymphomas that have the highest likelihood of presenting the translocations, namely all cases of BL-INT and DLBCLs with high proliferative kinetics (Ki-67 > 80%) and immunohistochemical overexpression of MYC (>40%) and BCL2 (>50%) [49]. The gene discussed is MYC; the disease is lymphoma.