They found UCA1 to be upregulated in A431 and CAL-39 cells following their exposure to cancer-associated fibroblasts (CAF)-derived exosomes, and CAF-derived exosomal UCA1 mediated DDP resistance to both cell lines by sponging miR-103a and upregulating mitosis inhibitor protein kinase WEE1. The gene discussed is WEE1; the disease is cancer.