MAPT and neurodegenerative disease: Conducting studies focusing on the search for early pathological events occurring in the nerve cells of people affected by neurodegenerative diseases, Haukedal et al. identified Golgi fragmentation as one of the earliest phenotypes of AD, occurring even before the phenomena of increased Aβ secretion and tau hyperphosphorylation, as well as mitochondrial and synaptic deficits [76].