Although persistent joint inflammation is not a life-threatening condition per se, continuous systemic inflammation accompanied by increased levels of tumour necrosis factor-alpha (TNF-α), interleukin (IL)-6 IL-6, IL-1, IL-12, IL-23, and immune system overstimulation may result in secondary amyloidosis and vascular disease as well [5].A reference to the RA patient’s life expectancy and most frequent causes of death confirms that systemic inflammation and vascular events are closely entangled [6]. The gene discussed is IL23A; the disease is rheumatoid arthritis.