Association of that gene with gastrointestinal/autonomic disease (M613662+, Table S2) qualifying the POLG variants of patients 116 and 460–473 of Table S3 with diagnostic utility for EDS, while its alternative association with neuromuscular (M607459+) diseases related the POLG variants of patients 60 and 82 in Table S4 to their developmental disability. The gene discussed is POLG; the disease is developmental disability.