Mutated in EDS patients to produce a common EDS–dysautonomia profile were genes previously associated (a) with other connective tissue dysplasias—ABCC6 [80], COL1 [58], COL3A1 [7], FBN1 [64], TGFB/BR [65,66,67], and ZNF469 [81]; and (b) with other types of EDS including heterozygous variants formerly involved with recessive diseases—ADAMTS2 [82], COL5 [43,56], FLNA [83], FKBP14, and LOX [84]. The gene discussed is ADAMTS2; the disease is dysautonomia.