Current matching of all mutations in a gene with one disorder (e.g., COL3A1 gene change to vascular EDS M130050), with one disorder type (e.g., COL5A2 gene change to classical type EDS-2, M130010), or especially with one component sign or symptom (e.g., FLG with scaly skin/ichthyosis, M146700) is a reason that so many DNA variations are qualified as the unhelpful variant of uncertain significance. Here, COL5A2 is linked to ichthyosis.