The latter gene’s association with hypermobile EDS is further supported when the individual finding frequencies of Table S1B (columns O-P, rows 11–13) are inspected: COL5A2 patients have significantly more child clumsiness and awareness of hypermobility, of Beighton maneuver and reverse prayer performance, in the HI-joint-flex class of findings, than the COL5A1 patients. The gene discussed is COL5A1; the disease is Ehlers-Danlos syndrome.