The group with collagen processing alterations (COLenzyme) shows few differences in joint-skeletal or other features in Table 3A, re-emphasizing that heterozygous mutations can produce typical EDS findings when operating in networks (44) and that even biallelic variants (as in patient 58 of Table S3 with PLOD3 lysyl hydroxylase-3 variants, M603066) will not necessarily produce a specific type of EDS. This evidence concerns the gene PLOD3 and Ehlers-Danlos syndrome.