The one significant difference in Table 2 was a higher percentage of patients meeting the criteria for hypermobile EDS in those having COL5A2 gene change, fitting with the association of COL5A1 gene changes with classical EDS (M130000, classical EDS type 1) but not with the similar association of COL5A2 gene changes (M130010, classical EDS type 2). The gene discussed is COL5A1; the disease is Ehlers-Danlos syndrome.