The emphasis on the skin by Ehlers and Danlos is fulfilled by (e) 14 patients with variants in skin-impacting genes (including 6 in both GJB2 associated with keratitis, M148210 and WNT10A associated with ectodermal dysplasia, M2570980+); (f) the 5 patients with COL7 or COL17 variants [61] associated with blistering skin diseases (M131750, M619787); and (g) the many (25 patients) with mutations in the aforementioned profilaggrin (FLG) gene with its scaly skin (M146700) and eczema (M605803) associations. Here, GJB2 is linked to keratitis.