Paracrine signaling is the neuronal activity that propels tumor progression, in the context of gliomas, via neuroligin-3 and BDNF [138,139,140], as well as through neuron-glioma synapses mediated by AMPA receptors, synapses which are modulated by BDNF [141,142,143]. The gene discussed is NLGN3; the disease is glioma.