Evidence is accumulating that suggests that complex interactions occur between these niches and glioma cells, with hypoxia being a pivotal factor in the induction of angiogenesis, triggering the upregulation of factors like vascular endothelial growth factor (VEGF), stromal cell-derived factor 1 (SDF1), platelet-derived growth factor (PDGF), and angiopoietins [126]. The gene discussed is CXCL12; the disease is central nervous system cancer.