Two genomic rearrangements, encompassing the starting instance of a gene fusion between the KDR VEGFR2 and the PDGFRA gene, along with six occurrences of PDGFRAΔ8,9, an intragenic deletion rearrangement. Notably, the PDGFRAΔ8,9 variant was prevalent, detected in 40% of GBM cases exhibiting PDGFRA amplification. Here, KDR is linked to glioblastoma.