MTDH and central nervous system cancer: Additionally, the Astrocyte elevated gene-1 (AEG1) has been identified as a critical molecule, analyzed through bioinformatic studies of human samples from The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), and the Chinese Glioma Genome Atlas (CGGA), complemented by in vitro cell lines and co-culture methods [97].