-Derailing of cell metabolism and aiding tumorigenesis.-Elevated 2-HG levels silence tumor suppressors and activate oncogenes.-Inhibiting differentiation of neural cells, promoting a stem-like state and tumor growth.-Metabolic and epigenetic shifts enhance genomic instability.-Reconfiguring the tumor microenvironment to diminish immune responses and bolster tumor viability.-IDH1 mutations are linked to improved outcomes. The gene discussed is IDH1; the disease is neoplasm.