-ATRX dysfunction triggers alternative lengthening of telomeres, which determine limitless division of cancer cells.-ATRX mutations interfere with chromatin remodeling while altering gene expression, which favors oncogenesis.-ATRX loss undermines DNA repair and chromosome segregation, escalating genetic variations conducive to tumor advancement.-Mutations in ATRX correlate with particular glioma subtypes, typically signifying an earlier age at diagnosis and unique molecular traits. The gene discussed is ATRX; the disease is neoplasm.