CMPK2 and type 1 diabetes mellitus: From the identified down-regulated genes, of note are Gsk3b (glycogen synthase kinase-3β), a critical regulator of cell proliferation and differentiation [83]; Chat (choline acetyltransferase), related to the ventricular remodeling in type 1 diabetes [84]; and Cmpk2 (cytidine monophosphate), involved in inflammatory diseases [85].