A study showed that C5BL/6J mice consumed a high-fat diet to induce obesity, whereas the administration of CK (15, 30, and 60 mg/kg) might successfully enhance the resistance to insulin and glucose tolerance, downregulate PPARγ expression, inhibit TLR4/TRAF6/TAK1/NF-κB stimulation in obese mice, and lower macrophage M1-type inflammatory cytokine levels in serum and adipose tissue in a dose-dependent manner. This evidence concerns the gene PPARG and obesity due to melanocortin 4 receptor deficiency.