However, before the animals were induced into AD mode, NTU 101 was administered orally in advance, which could increase the ratio of CD4+/CD25+/FOXP3+ in the spleen, but the ratio of CD4+/IL-4+ also increased, while there is no difference in the ratio of CD4+/IFN-γ+ and CD4+/IL-17+, and the content of total IgE antibody in serum increases. The gene discussed is CD4; the disease is Alzheimer disease.