Of course, we do not suggest that this is the only chemokine that astrocytes use to influence the inflammatory milieu, nor do we suggest that androgens (or even AR itself) exert their documented beneficial physiological effects exclusively via the mechanism that we identified, but the fact that this signaling axis is theoretically possible in vivo is important for the interpretation of physiological phenomena such as sex differences in disease penetration or hormonal effects in MS. Here, AR is linked to myeloid sarcoma.