AD is currently the most common brain aging disorder, indicated by the progressive age-dependent loss of memory, increased prevalence of extracellular amyloid plaques that originate from the processing of amyloid precursor protein (APP), and intracellular neurofibrillary tangles (NFTs) made from hyperphosphorylated tau protein (pTau) in the CNS. This evidence concerns the gene MAPT and Alzheimer disease.