PICALM and Alzheimer disease: In any case, many more genes need to be investigated, such as the bridging integrator 1 (BIN1), clusterin (CLU), and phosphatidylinositol-binding clathrin assembly protein (PICALM), which have been previously shown to be associated with increased risk for late onset AD [54] and also predict objective verbal memory (p < 0.05) [59].