SPP1 and cancer: For SPP1 in the EMT pathway, whose expression increases in the transition from healthy to low serous, there is a moderate correlation between its expression and T cell in low serous tissue (r = 0.4, p = 0.017), a moderate negative correlation between B cell in low serous tissue (r = −0.39, p = 0.019), a moderate negative correlation between macrophage–monocyte in low serous tissue (r = 0.43, p = 0.0088) and a moderate correlation between cancer-associated fibroblast in borderline and low serous tissue (r = 0.37, p = 0.