AGTR1 and Hypertension: (2) In uterine artery rings, T affects the endothelium-dependent relaxant pathways, with EDHF and PIG2 being the most affected; other authors have demonstrated an imbalance between angiotensin II receptors type 1 and 2, with the latter downregulated when compared to AGTR1, a suggested mechanism that could explain hypertension in PE [63].