Therefore, more randomized controlled studies are needed to enhance the reliability of the results, considering various influencing factors such as age, sex, population, ethnic, and regional differences, genetic predisposition to IBD, IBD subtypes (UC or CD) and disease activity, the type of H. pylori detection test, virulence of H. pylori strains (CagA-positive or CagA-negative), and H. pylori eradication outcomes (treatment efficacy and adverse events). This evidence concerns the gene S100A8 and inflammatory bowel disease.