Despite H. pylori CagA-positive strains demonstrating higher pathogenic and carcinogenic potential (being found in approximately 90% of biopsies from patients with severe gastric diseases, such as peptic ulcer, mucosa-associated lymphoid tissue lymphoma (MALToma), and gastric adenocarcinoma), they have also been strongly associated with a protective role against IBDs [2,7]. This evidence concerns the gene S100A8 and MALT lymphoma.