At present, significant effort has been placed into the study of the anti-tumor therapeutic mechanism of several cytokines, such as IL-2 [122], IL-12 [123], IL-15 [124], IL-24 [125], IFN-γ [126], IL-1β [127], TNF-α [128], GM-CSF [129], and others [130]. This evidence concerns the gene IFNG and neoplasm.