TSC1 and rhabdomyoma: However, the question that remains unanswered is whether mutations in either the TSC1 or TSC2 genes can lead to abnormalities in action potential formation or impaired calcium homeostasis and signaling, which in turn trigger abnormal impulses in cardiomyocytes without structural distortions, while rhabdomyoma serves as an obstacle to break the wavefront and generate arrhythmic premature stimuli.