TIA1 and neoplasm: In the same line, the dual role of TIA1/TIAR proteins as tumor suppressors and enhancers in a cell/tissue type-dependent way in tumorigenesis suggest overlapping, cooperative and/or antagonistic regulatory roles between its protein variants [23,34,35,36,37,38] and the complexity of the combinatorial dynamic nature of RNA–RNA and RNA–protein interactome at the crossroads with heterogeneous populations of protein non-coding and/or encoding RNAs and other additional RBPs [4,6,74].