Positive cytoplasmic and nuclear Erα immunostaining was also observed in the glandular, luminal epithelium, and undifferentiated uterine stroma located between the inter-implantation site luminal epithelium and the myometrium, which was not different between hypertensive BPH/5 and normotensive C57 pregnancies (Figure 3c,d, p > 0.05). The gene discussed is ESR1; the disease is benign prostatic hyperplasia.