In terms of the GO functional enrichment, driver genes were significantly enriched in some GO-BP terms; for example, the transformation of cellular proto-oncogenes into oncogenes leads to the over-activation of these signaling pathways, which in turn interact with the PI3K-Akt and Ras-ERK pathways to dysregulate cancer signaling and generate tumor cells [44]. Here, AKT1 is linked to cancer.