We applied SAGO on selected datasets that capture large genomic regions including large (106–107 bp) H3K27me3 and H3K9me3 domains obtained by ChIP-seq [25,26,27], regions transitioning from compartment B to A upon ES differentiation to NPC as determined by HiC data [28], lamin-associated domains (LADs) in the liver [29] and regions with copy number alterations observed in cancer patients [30]. Here, LMNA is linked to cancer.