Further, oxidative stress and reactive oxygen species (ROS) contribute to the development of cardiac hypertrophy [25], where they activate signaling kinases and transcription factors, such as mitogen-activated protein kinase (MAPK), which mediates inflammasome formation and the processes of the proinflammatory cytokines interleukin IL-1β and IL-18 via caspase-1 activation [26]. Here, CASP1 is linked to cardiac hypertrophy.