Paternal HFD exposure leads to a reduced rate of ongoing pregnancy, decreased fetal and placental weights, delayed limb morphology, a decreased crown-rump length, and an increased risk in the offspring of chronic kidney diseases and metabolic syndrome-like characteristics; most recently, this has been found to occur through the transmission of β-cell dysfunction and glucose intolerance in F1 female offspring and altered insulin sensibility in F1 male offspring [83,92,93]. Here, INS is linked to Glucose intolerance.