MTHFR and Rare hereditary thrombophilia: Although there are contradictory reports available, with regard to the association of maternal thrombophilia with adverse pregnancy outcomes, there is extensive literature about the role of certain maternal thrombophilic mutations, including Leiden Factor V (rs6025), of the gene for prothrombin (20210G > A) (rs1799963), of methylenetetrahydrofolic reductase (MTHFR 677C > T) (rs1801133) in recurrent abortion [10,11].