GSTM1 and malaria: Hematin (ferric (Fe3+) PP IX liganded with OH−) is formed predominantly during malaria RBC invasion as a by-product of the parasite’s digestion of host cell hemoglobin (Hb), while hemin (Fe3+ PP IX liganded with Cl−) is constantly produced in the human body during the reactions of Hb autooxidation either spontaneous or disease-triggered (Supplementary Figure S1) [10].