After IR in human glioma LN229 cells with silencing of SIRT3 expression, there was worsened oxidative damage to mtDNA, as measured by the accumulation of 8-oxoG and Δ-mtDNA4977 deletion, resulting in more severe mitochondrial dysfunction and increased apoptosis compared to cells without SIRT3 inhibition [197]. The gene discussed is SIRT3; the disease is central nervous system cancer.