Recently, it has been shown by our research group that the high-risk oncogenic HCMV strains have the capacity to induce Myc/EZH2 expression and induce the formation of polyploid giant cancer cells (PGCCs), suggesting a potential association between HCMV infection, elevated Myc/EZH2 expression, and polyploidy in vitro and in several tumors [14,15,16,17]. This evidence concerns the gene MYC and cancer.