TAMs play a role in various processes such as angiogenesis (secretion of vascular endothelial growth factor, VEGF; transforming growth factor beta, TGF-β; matrix metalloproteinases, MMPs), migration, and invasion (secretion of MMPs; epidermal growth factor, EGF; serine proteases), EMT (secretion of TGF-β), intravasation and extravasation (production of CCL18 chemokine), and interaction with cancer stem cells, and ultimately contribute to immunosuppression (expression of PD-L1/PD-L2, production of IL-10, TGF-β, arginase-1, and prostaglandins) [95,96]. The gene discussed is VEGFA; the disease is cancer.