EZH2 expression was observed in the majority of cancer cell lines and xenografts possessing mutations of the SWI/SNF subunits AT-rich interaction domain 1A (ARID1A); polybromo-1 (PBRM1); and SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 4 (SMARCA4), which are some of the most commonly mutated SWI/SNF subunits in human cancer [33]. Here, PBRM1 is linked to cancer.