In the context of GBM, HCMV-GBM strains isolated from GBM biopsies induced a CEGBC phenotype exhibiting upregulated EZH2 and Myc with tumor heterogeneity, proneural-to-mesenchymal plasticity, as well as stemness resulting in spheroid formation and invasiveness [15]. Here, EZH2 is linked to glioblastoma.