HUWE1 and osteosarcoma: This is the case of HECT, UBA, and WWE Domain Containing E3 Ubiquitin Protein Ligase 1 (HUWE1), which inhibit osteosarcoma proliferation by inhibiting the Wnt signaling and by preventing accumulation of c-Myc [20,21], and of F-Box And WD Repeat Domain Containing 7 Protein (FBXW7), that blocks the cell cycle G1/S transition and proliferation in osteosarcoma cells [22].