TP53 and cancer: Although data about the role of the DUBs in p53 stabilization are lacking in osteosarcoma, the potential role of deubiquitinases, such as OTU Deubiquitinase (OTUD) 1, 3 or 5, in p53 deubiquitination could be investigated [83] in order to achieve reduced p53 degradation and consequent cancer cell death.