A recent study demonstrated that the N-glycosylation of a Wnt ligand, its receptors, and E-cadherin promotes the expression and nuclear translocation of β-catenin/γ-catenin that upregulates the transcriptional activity of dolichyl-phosphate N-acetylglucosamine phosphotransferase 1 (DPAGT1), which results in tumor progression and metastasis in oral cancer. This evidence concerns the gene CDH1 and neoplasm.