The mammalian target of rapamycin (mTOR) plays an important role in osteosarcoma progression, as its pathway, the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mTOR pathway, regulates a plethora of cellular processes, from cell growth and proliferation to metabolism and survival [23]. The gene discussed is AKT1; the disease is osteosarcoma.