To address this challenge, several AKI biomarkers, including NGAL [10], KIM-1 [11], IL-18 [12], L-FABP [13], and TIMP-2*IGFBP-7 [14,15] have been identified as predictors of the onset of AKI, the severity of AKI, and renal prognosis of AKI in critically ill patients. This evidence concerns the gene IL18 and acute kidney injury.