To address this challenge, several AKI biomarkers, including NGAL [10], KIM-1 [11], IL-18 [12], L-FABP [13], and TIMP-2*IGFBP-7 [14,15] have been identified as predictors of the onset of AKI, the severity of AKI, and renal prognosis of AKI in critically ill patients. Here, LCN2 is linked to acute kidney injury.