Yet, as was demonstrated more than 10 years ago by Azijli and co-workers, in the TRAIL-resistant cancer cell line A549, TRAIL induces, in addition to NF-κB, the phosphorylation of a large number of substrates associated with activation of the P38, ERK1/2, JNK1, Src, AKT, Raf1 and ROCK [364]. The gene discussed is AKT1; the disease is cancer.