CASP8 and rheumatoid arthritis: Consistent with the findings described above and the work of Henry et al. [397], indicating that both FADD and caspase-8 may account for TRAIL non-apoptotic signalling, is the demonstration, in rheumatoid arthritis fibroblast-like synoviocytes, that caspase-8 is responsible for the cellular migration of these synoviocytes stimulated with PDGF, regardless of its enzymatic activity [467].