Besides regulating metastasis, uPAR was found to inhibit TRAIL-induced apoptosis by regulating, the expression of DR4 and DR5 in glioma cells [475], the intrinsic mitochondrial pathway in colon cancer [474] or miR-17 and miR-20 expression levels in TNBC, two miRNAs that were shown to impair DR4 expression [476]. This evidence concerns the gene TNFRSF10A and central nervous system cancer.