While the implication of TRADD for TRAIL signalling is less investigated, TRADD was found to afford protection against TRAIL-induced apoptosis [355,365,366], but more interestingly TRADD was suggested to play an important role in the secondary complex to induces IL-8 secretion in NSCLC, under TRAIL treatment [367]. The gene discussed is TRADD; the disease is non-small cell lung carcinoma.