In cancer cells, on the other hand, if apoptosis is not efficiently triggered, TRAIL can be detrimental to patients given that this cytokine also exhibits pro-tumoral properties, associated with TRAIL’s ability to induce inflammation, tumour cell motility and invasion, ultimately leading to metastasis [8,11,12,114,343,344,345,346,347]. The gene discussed is TNFSF10; the disease is cancer.