TNFSF10 and neoplasm: Likewise, although much less efficiently than TNFR1, both TRAIL and Fas-ligand agonist receptors are able to trigger NF-kB signalling, leading in some cases to increased tumour growth and inflammation [16,17,18,19,20,21,22,23,24,25,26,27,28,29,30] (Figure 2).