Finally, TRAIL may also play a role in allergy, given that eosinophils and granulocytes express TRAIL receptors, but are insensitive to TRAIL-induced cell death [307,308], TRAIL is abundantly expressed in the airway epithelium, in response to allergen provocation, in the initial step [308,309,310]. The gene discussed is TNFSF10; the disease is Allergy.