TP53 and cancer: Therefore, given that DR4 and DR5 are usually upregulated in cancer cells [258,259,260,261,262,263,264,265,266], and that TRAIL induces apoptosis in a p53-independent manner [267,268], contrary to most chemotherapeutic drugs [269], overcoming p53 escape [40], TRAIL attracted major attention in oncology [270,271,272,273].