Increases in principle pathways/components such as the TGFβ1/Smad pathway, platelet-derived growth factor (PDGF)/AKT pathway, galectin-3, transglutaminase 2, lysophosphatidic acid 1 (LPA1), and lysyl oxidase-like 2 (LOXL2) have been reported in the bleomycin model and human IPF as critical contributors in driving fibrogenesis [27,28,29,30,31,32,33,34,35,36]. The gene discussed is LGALS3; the disease is idiopathic pulmonary fibrosis.