Over 50 disease-modifying genes have been identified for ALS [194]; mutations in chromosome 9 open reading frame 72 (C9ORF72) [195], CuZn superoxide dismutase type-1 (SOD1) [196,197], TAR DNA-Binding (TARDBP) [198], and fused in sarcoma (FUS) [PMID: 19251627] [199], account for 70% of all cases of fALS. Here, TARDBP is linked to amyotrophic lateral sclerosis.