ABCB1 and hepatocellular carcinoma: Similarly, Gou et al. [29] aimed to investigate whether the use of polysaccharides extracted from the mushroom Trametes robiniophila Murr could negatively regulate the expression of microRNAs that target the MDR1 gene and, consequently, regulate the levels of the P-gp protein and thus increase the sensitivity of hepatoma cells to oxaliplatin [29].