LGR5 and neoplasm: The isolated compound inhibited tumour proliferation, suppressed tumour growth and reduced chemoresistance, negatively regulating oncogenic signalling pathways important for stem cell maintenance, including Lgr5/Wnt/β-catenin, JAK-STAT and receptor tyrosine kinase, as well as inducing the downregulation of aldehyde dehydrogenase and other stem cell-related factors.