MKI67 and ovarian neoplasm: In addition, the results showed that the tumours in the combined treatment group had a significantly reduced Ki-67 level (a marker of the cell proliferation rate), as well as a higher TUNEL (indicative of apoptosis) fluorescence intensity, suggesting that the combination of SBSGL with cisplatin further suppressed proliferation and promoted apoptosis of ovarian tumours in vivo [32].