Given our lab’s main focus on understanding neurodegenerative disorders such as Alzheimer’s disease (AD), where presenilin-1 (PSEN1) mutations play a central role, we used two commercially available hiPSC lines: 10-C and the isogenic counterpart carrying the E280A mutation in the PSEN1 gene (PSEN1 +/+) [12]. The gene discussed is PSEN1; the disease is early-onset autosomal dominant Alzheimer disease.