SOCS3 and Alzheimer disease: In addition, a study conducted on the polymorphism of the IL-6 promoter region (IL-6 174-G/C) in patients affected by AD reported that genotypes with a protective effect presented high levels of SOCS3, which were associated with the presence of high levels of IL-6 detected in the serum, so the authors suggest that SOCS3 together with IL-6 could be potential indicators of diagnosis/prognosis in atopic diseases including AD [121,122].