SOCS3 and psoriasis: Furthermore, histological analysis of the skin of these psoriatic patients revealed peculiar epidermal thickening following upregulation of both SOCS1 and SOCS3 [88] and that the increased expression of SOCS1 levels in keratinocytes of psoriasis patients and activated by IFN-γ is not sufficient to counteract the detrimental effects of this cytokine [89].