The SOCS protein family, well known as negative regulators of cytokine signaling by interfering with the binding of cytokine receptors and the intracellular molecules that act downstream, such as JAKs and STATs, could be involved also in modulating the JAK/STAT pathway in AD and related diseases such as allergic rhinitis, asthma, and food allergies [23,106,107]. Here, CISH is linked to Alzheimer disease.