The zinc finger FYVE-type containing 26 (ZFYVE26, also named Spastizin) can interact with Rab5 and Rab11, and the hereditary spastic paraparesis-related mutation of ZFYVE26 leads to a defect in the fusion between autophagosomes and endosomes, implying that ZFYVE26 may be involved in amphisome formation. This evidence concerns the gene ZFYVE26 and hereditary spastic paraplegia.